Production Scanners

Data integrity is a primary focus of the FDA, and will continue to be so until the pharmaceutical industry takes meaningful corrective actions to address shortcomings in this area.

When Plainfield, IN, needed to double their permitted capacity from 2 MGD to 4 MGD at their South wastewater treatment plant, they faced a dilemma. Like most treatment plants, space is at a premium, and compact design was needed not only for the current expansion, including the addition of a post aeration structure, but to preserve as much room as possible for projected future expansions.

The Escalon Industrial Waste Water Treatment Facility’s service area is seasonal and centered on tomato and pickle processing. The production season (roughly mid-July through mid-October) sees high hydraulic- and BOD loads that strain the facility’s capacity. During the high season highly variable BOD load depletes DO and causes permit violations and odor complaints. Praxair installed 4 X 15 HP Medium Velocity Oxygenation (MVO™ oxygenation system), with the ability to deliver up to 6 TPD of oxygen to supplement the existing aeration capacity at the facility.

Malta is an archipelago of three islands situated in the Mediterranean Sea, around fifty miles south of Sicily. There are no rivers of any significance on the islands, and the sparse annual rainfall is only about 500 mm. There is a water deficit in Malta. It occurs especially in summer when there is a great demand from the farmers for their irrigation and from the tourism sector.

Airflow visualization testing, conducted as part of a routine review program, can help assure that aseptic filling areas remain under a state of proper control.

In the lifecycle of pharmaceutical and biopharmaceutical commercial manufacturing, the one constant has been change. With the advent of modern therapeutics, large scale commercial manufacturing became common place.

Ensuring the availability and maximizing the capacity of your assets is critical to success. Many assets are also part of more complex and larger networks of equipment, and appropriate maintenance may rely on efficiently managing shutdown projects and/or remotely identifying asset health and condition. A robust Asset Management system will help organizations in all sectors of the manufacturing industry with specific needs while maximizing asset performance.

Investing in integrated business software is a large undertaking and not something to be taken lightly. This article addresses the tasks and processes involved in implementation and how to overcome them.

To help meet the needs of both large- and small-scale operations, suppliers of sterilizing-grade filters have developed new products and technologies to help meet the needs of today’s biomanufacturing processes. Industry trends toward intensified processing and increased implementation of single-use systems are changing approaches to sterile filtration and bioburden control in biomanufacturing processes.

Fujifilm began to look at single-use technology, as it showed real potential to reduce the cost and timeline of development considerably. But would it offer the same performance as stainless steel?

Union Cements Company (UCC, Ras Al Khaimah), founded in 1972, is one of the biggest cement manufacturers in the UAE for Portland cement with capacity of 10,000 tons per day.

This article examines some of the currently available schemes used in generating rAAV from suspension cultures, and describes what it takes to achieve scalable rAAV production.