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WHITE PAPERS AND CASE STUDIES

• IQ, IR, And Single Sideband Mixer Primer

  This application note introduces IQ, single sideband (SSB), and image reject (IR) mixers in both theory and practice. We will discuss basic applications, their concepts, and practical considerations in their selection and use.

• Retention Improved In A Pompe Disease Clinical Trial

  Explore the ways one double-blind, randomized Phase 3 study was able to boost the participant’s overall adherence to the protocol and increase their willingness to continue with the trial.

• Creating Sustainable Data In The Laboratory

  In a laboratory setting, data is everywhere. Learn in-depth about data challenges, the importance of data lifecycle management in laboratories, and the need for data sustainability.

• Antibody-Drug Conjugates: 'Magic Bullets' Become Reality

  Cancer therapy has evolved from potent chemotherapy to targeted biological therapy, including antibody-drug conjugates (ADCs). Learn more about ADCs’ makeup, mechanisms, and the development landscape.

• Evaluating And Improving Apheresis Material Cryopreservation Processes

  Cryopreservation of apheresis offers many advantages but still presents manufacturing challenges such as cell clumping. The process requires attention in future studies as autologous cell therapies mature.

• Preclinical Evaluation Of Antifibrotics In COVID-Induced Fibrosis Model

  Advancing the development of effective antifibrotic therapies requires urgent investment in clinically relevant, IND-enabling preclinical models to address the growing burden of fibrotic diseases.

• The EMR Interoperability Dream Vs. Clinical Research Reality

  Seamless Electronic Medical Record access promises accelerated trials and regulatory-grade evidence, but incomplete, unstructured data requires hybrid strategies using AI and human oversight to bridge gaps.

• How To Adopt CSA For Streamlined Computer System Validation

  Discover how the FDA’s Computer Software Assurance guidance modernizes validation by reducing compliance burdens and fostering innovation through a streamlined approach to system validation.

• Addressing The Challenges In Lentivirus Harvest Clarification

  Traditional depth filtration struggles with lentiviral harvest clarification, leading to low yields and high costs. However, single-use centrifugation offers a promising alternative.

• Assuring Multipotency Of Human Mesenchymal Stem Cells (hMSCs)

  Stem cell research has revolutionized tissue repair and regenerative medicine. Discover how mesenchymal stem cells play a key role and offer insights into connective tissue repair, immune response, and inflammatory diseases.

• Modelling TPDs Utilizing Computational And Medicinal Chemistry Approaches

  Through a carefully executed strategy, see how we identified novel degrader molecules with the right physicochemical properties to achieve robust degradation of the target Protein of Interest (POI).

• Improve Your Molecular Cloning Process With Synthetic Biology Automation

  Explore the promising field of synthetic biology, the hurdles manufacturers face with it's workflow, and how automation can help accelerating throughput and walkaway time.