What Does An Endpoint Adjudication Committee (EAC) Do?

Endpoint adjudication committees (EACs), also known as clinical event committees (CECs), serve a critical role in clinical research by determining whether a research participant’s individual medical event meets the protocol’s pre-defined criteria. They can also provide specific therapeutic expertise beyond that of the principal investigator (PI) or medical monitor. This white paper discusses the EAC’s role in research, the basics of setting up an EAC, and regulatory context on why it is so important for the committee to be completely separate from study conduct.