DynaPro NanoStar Dynamic Light Scattering Instrument

WYATT DynaPro NanoStar

The DynaPro® NanoStar® II is a unique cuvette-based DLS instrument used for the analysis of proteins, gene therapy vectors, viruses and virus-like particles, promiscuous inhibitors, micelles, liposomes, lipid and metallic nanoparticles, and more.

Traditional dynamic light scattering, just better.

Unique cuvette-based DLS

To accommodate scarce and precious samples, specially designed quartz cuvettes afford robust, accurate measurements with as little as 2 µL of solution, while our proprietary disposable cuvettes provide comparable sensitivity with as little as 4 µL!

Walk-up operation with DYNAMICS® Touch

The NanoStar is the only DLS instrument to provide a fully integrated, walk-up measurement experience. No need to boot up your lab PC, launch the DLS software, connect to the instrument and worry about where your data files are stored. DYNAMICS Touch is an intuitive—yet capable—DLS measurement app that resides right on the NanoStar. Via the full-size touch screen display, DYNAMICS Touch guides you through the entire setup and measurement process. It tells you if the data quality is sufficient for confidence in the results, and displays them instantly. Data files and concise PDF reports can be stored on the instrument, transferred via the network or downloaded to a flash drive. You can even send the report to your phone!

Full-featured analyses with DYNAMICS®

DYNAMICS is our powerful PC-based, comprehensive software package for collecting, analyzing, and reporting batch dynamic and static light scattering data. It performs advanced analyses and compares multiple data files to identify trends and statistics. DYNAMICS can control the NanoStar and acquire data directly, or read in DYNAMICS Touch data files.

DYNAMICS is offered with a 21 CFR Part 11 compliant Security Pack option, enabling the use of the DynaPro NanoStar in a GMP environment for quality control or at-line process monitoring.

Size and beyond

Coupled with the versatile and user-friendly DYNAMICS software and DYNAMICS Touch on-board app, the NanoStar may be utilized to measure not just size, size distributions, particle concentration and weight-average molar mass, but also solution properties relevant to sample stability: the second virial coefficient (A2 or B22), the diffusion interaction parameter (kD), and the temperature of protein melting or aggregation onset (Tm, Tonset).

Cuvette, and yet...

... still another feature unique to the NanoStar: the optical fiber pickup may be coupled to any of Wyatt's on-line MALS detectors - the DAWN® or miniDAWN® - to add on-line DLS measurements in the same detection volume as SEC-MALS or FFF-MALS measurements. 

Combining numerous benefits, the NanoStar is an unparalleled cuvette-based DLS detector. For higher productivity, consider the DynaPro Plate Reader, the only commercially available DLS plate reader measuring in situ for high-throughput screening of thousands of conditions per day in industry-standard microwell plates.