White Paper

3D Manufacturing Of Therapeutic hMSCs With RoosterNourish™-XF & beadMATRIX

How To Transfer Cell-based Potency Assays Into A GMP Environment And Maintain Performance

The production of standardized, well-characterized, and high-quality human mesenchymal stromal cells (hMSCs) in clinically sufficient quantities is an area of great interest in biomanufacturing. Here, we established the beadMATRIX technology, a microcarrier-based technology by denovoMATRIX, as a new valuable tool for cell-based therapies. Since the hMSCs maintained their identity, differentiation, and immunomodulatory capacity, beadMATRIX will contribute to meeting the economic and quality goals of hMSC manufacturing processes.

Combining RoosterNourish™-XF medium with beadMATRIX microcarrier for the expansion of hMSCs in a bioreactor setup enables a clinically relevant degree of hMSC proliferation while maintaining hMSC identity and potency. Discover how harvested hMSCs shows high proliferation capacity, expression of hMSC-specific markers, significant trilineage differentiation potential, as well as strong immunomodulatory and angiogenic potency. 

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