Customized Solutions For Special Projects- Systems To Match Your Cultivation Requirements

The Applikon BioProduction is ideal for the following applications:

• Microbial and cell culture
• Batch, Fed-Batch, Perfusion and Continuous cultivation

Built for your needs and application

• Complete turnkey system with automation
• Wide choice of controllers with many PLC and DCS options
• Design, fabrication and automation based on collaborative approaches and project managed with your inputs at every stage

The processing steps towards building the most optimal cultivation system can be complex, requiring tailor-made systems. Using modern design technologies, we will guide you through the process - from concept stage to installation. Our systems can be configured to various applications, whether microbial or cell cultures, and can be customized to specific requirements like custom volumes, cleaning solutions, access platforms, control solutions and materials. 

Choose the best options for your goals; skids on wheels or permanent mounts, mobile or stationary Clean-In-Place with or without automation. Complementary media prep, harvest and inactivation systems can be supplied as well. Design any system to suit your needs.

Essential in producing vaccines and medicines

Bioreactors play a key role in producing life-saving vaccines and medicines. This complex process requires highly optimized, state of the art systems. With the Applikon BioProduction, we provide ease and flexibility of customizing the vessels to handle any type of application needs.

Do you know...

• we have supplied stainless steel bioreactors for over 30 years
• GMP stainless steel bioreactors are one of our specialties
• we have supplied hundreds of production bioreactors worldwide
• you can combine add-on packages to upgrade your bioreactor

Developing life-saving biological drugs requires production bioreactor systems that meet strict GMP regulatory requirements to ensure the highest quality drugs for human and animal use. Getinge supplies production scale GMP bioreactor systems that provide full automation, cleanability and traceability so that patients around the world receive safe and effective medicines in a timely manner. Our reactor manufacturing environment (Delft, NL) strictly follows GMP and ICH guidelines. With full control and automation and GMP documentation, whether you require a single bioreactor from 15 to 5000 L or an entire seed train that fits perfectly in your facilities, we have the right system for you.

#GrowWithUs

Applikon BioProduction Features

Easy to validate- The stainless steel bioreactors and fermenters are built to the latest standards on hygienic processing, meeting cGMP and GAMP requirements, and can be supplied with an extensive documentation package to support efficient validation.

Easy to operate- Stainless steel bioreactors minimizes the risk of contamination as there are no consumables to be replaced for every single run. Furthermore, these Sterilizable-in-Place bioreactors are supplied with magnetic coupled agitator connections. Whereas the agitator shaft continues from the outside to the inside of the bioreactor with traditional connections (lipsealed or double mechanical seal), here the connection is established via magnets. Since there is no connection with the outside world, there is no risk of contamination.

The open frame construction gives easy access for maintenance and operation.

Easy to clean- The Applikon stainless steel bioreactor range is completely fabricated using pharma-grade 316L stainless steel and supplied with a surface finish of Ra < 0.4 micron. This smooth surface ensures that biofilms and debris will not stick to the internals of the bioreactors. This greatly simplifies the cleaning procedure and creates ease of mind knowing that the bioreactors will always be reproducible clean.