An efficient feeding system can offer significant return on investment thanks to higher accuracy and better control, despite the higher initial capital investment.
Twin screw feeders are often used as the dispensing and feeding method of choice for difficult flowing pharmaceutical powders. Both gravimetric and volumetric devices are used for a variety of pharmaceutical unit operations including batching operations to reactors and bins, feeding to mills and micronizers, and tablet press lubrication. In addition, high accuracy gravimetric feeders have now become the “heart” of the pharmaceutical continuous process, including continuous direct compression, continuous extrusion and granulation, continuous dry granulation and continuous coating. Base prices of most standard feeders can start as low as $20,000 for volumetric pharmaceutical applications. However, it is important to note that a wide variety of options exist for “pharmaceutical design” feeders, each of which result in a variety of price points. This article will outline several of the options available for pharmaceutical feeder applications and also define the process advantages when considering these options.
Figure 1: Coperion K-Tron twin screw feeder with ActiFlow™ bulk solid activator. ActiFlow eliminates headroom concerns, reduces cleaning and product changeover time and in turn lowers overall production labor cost.
Volumetric or Gravimetric
As stated above, screw feeders are available in both volumetric and gravimetric loss-in-weight (LIW) designs. In general, due to the added cost of the controls and weigh scale or load cells, a gravimetric feeder will be at a higher price level than a volumetric feeder. A volumetric feeder feeds a certain material volume per unit of time (such as cubic feet or liter per hour) to a process. The bulk material is discharged from a hopper with a constant volume per unit of time by regulating the speed of the feeding device. In general, the feeding accuracy of any volumetric feed device is dependent upon the uniformity of the material flow characteristics and the bulk density. (Figures 2 and 3 illustrate the volumetric versus the gravimetric feeding principle.)
Dependent upon the applications, volumetric feeders can sometimes be the technology of choice. For example, in many milling and micronization applications, volumetric feeders are used in lieu of gravimetric when consistency of volumetric feed is important, and high accuracy of mass flow is not a concern. In order to optimize the consistency of the volumetric feed, however, it is important to investigate feeder suppliers which incorporate feed screw modulation into their control algorithms. Feed screw modulation is a method of minimizing the pulsations which may occur as material is discharging from the screw, thus optimizing the consistency of flow.
Unlike the volumetric screw feeder, a LIW directly measures the material’s weight to achieve and maintain a predetermined feedrate that is measured in units of weight per time. The bulk material is discharged from a hopper by weighing the material being fed and regulating the speed of the feeding device. The weighing system with control compensates for non-uniform flow characteristics and variations in bulk density, and therefore provides for a high degree of feeding accuracy. The feeders control and dictate the total massflow to the process below. For these reasons, gravimetric feeders are the feeders of choice for continuous processes and are often called the “heart” of the continuous process.
Figure 2 - Volumetric feeder principle: A volumetric screw feeder feeds a certain material volume per unit time to a process.
It is important to note that if the material being fed has a tendency to bridge or create ratholes in a feeder hopper, a LIW feeder will detect these occurrences quickly, due to the lack of weight loss in the hopper. A volumetric feeder will continue to run at the speed set, thus possibly resulting in a period of time where little or no material is fed to the process below. For this reason, even in applications where a volumetric feeder may be suitable, the added cost of a LIW feeder may be considered a profitable investment ensuring process reliability and end product quality.
Figure 3 - Gravimetric loss-in-weight feeder principle: A loss-in-weight (LIW) feeder is a gravimetric feeder that directly measures the material’s weight to achieve and maintain a predetermined feedrate that’s measured in units of weight per time.
Load Cell Accuracy and Resolution
Any LIW process controller requires accurate high-speed measurement of material weight changes in order to provide optimal feeder control and performance, especially on a second-to-second basis. The weighing system must also be able to filter out erroneous measurements due to in-plant vibrations or disturbances and be stable over changes in process room or process material temperatures. The higher the resolution of weight measurement and the faster those weight measurements are taken, the better the information that will be provided to the control algorithm and the better any vibration filtering algorithm will work. In addition, almost all weighing systems provide temperature compensation. The exact warranted temperature range should be verified, as this can affect the long term stability of the feeder performance.
When evaluating gravimetric feeder technologies, it is important to understand both the weighing technology resolution as well as the responsiveness of the control system. Both of these important attributes will greatly affect the resultant accuracy of the feeder, which in turn can have a significant effect on overall ingredients dispensed and the resultant costs and/or the quality of the end product. These attributes are also very significant for low mass flow rates, such as those which may apply for low formulation percentage API’s and also for any required high second-to-second accuracy.
Materials of Construction and Surface Finish
Most feeders for pharmaceutical applications include stainless steel for all product contact surfaces, with a preference towards 316 type steel. It should be noted that some manufacturers offer 316L as the standard, due to its higher corrosion resistance, particularly in relation with the cleaning agents used. Surface finishes usually include a minimum of 0.8 micron Ra for all product contact surfaces. It is important to verify with the feeder manufacturer the options available for both surface finish and surface treatments (e.g. electropolishing) as these may be added costs. In addition, it is important to discuss with the feeder manufacturer the flow properties of the materials being fed, and how options on different surface treatments or finishes may affect the flow through the feeder. For example, higher surface finishes (e.g. typically below 0.2 micron Ra) may not improve flow, but may actually impede it, due to the change in surface tension of the stainless steel. In addition, for very poor flowing materials, there may also be options for surface treatments such as PTFE coatings.
Since materials of construction and surface finish standards may differ from manufacturer to manufacturer, it is imperative that the end-user discuss all the options and price levels available. A manufacturer with extensive experience in handling difficult flowing ingredients, like Coperion KTron, will be able to easily recommend the best and most cost effective combination for your application.
Single or Twin Screw Feeders
Screw feeders represent the most versatile feeding technology for most bulk solids. Given the material characteristics, a variety of screw configurations varying in both screw pitch and diameter are available to cover a wide variety of feed ranges. In addition, screw configurations can be single or twin screw design, as shown in Figure 4.
Figure 4 - Basic single and twin screw geometries
Of special note is the basic distinction between the material handling capabilities of twin screw versus a single screw design. Where two screws intermesh and co-rotate, the result is the formation of relatively sealed, forward moving pockets of material. Thus, the twin screw acts similar to a positive displacement pump and first captures floodable or poor flowing materials, and then forcibly moves them to discharge.
An added advantage is the self-wiping action of the screws that helps to keep the screw surfaces clean and free of build-up. Single screws, whether in a spiral or auger type design, do not possess this type of pumping action, and thus are not recommended or appropriate for floodable or cohesive, poor flowing materials. Due to the high turndown ratio and flexibility of design, screw feeders can also be provided to feed extremely accurately at rates as low as 20 g/h, with screws as small as 12 mm in diameter. These smaller screw feeders, such as the Coperion K-Tron Microfeeder (Figure 5), can be ideal when feeding micro ingredients, such as API’s or lubricants in a continuous process.
Figure 5: Coperion K-Tron gravimetric Microfeeder K-CL-SFS-MT16 (left) and volumetric Microfeeder K-CV-MT12 CK (right).
In general, for equivalent required feed rates, single screw feeders will be less in cost than twin screw feeders. However, as stated above, it is important to note the performance improvement which may be resultant in a twin screw feeder, thus resulting in more accurate feeding and overall ingredient cost savings.
Flow Aids for Improved Feeder Performance
It is important to note that the accuracy of any screw feeder is largely dependent upon consistent screw fill. A flow aid device may be required in or on the feeder’s hopper to assure that the process material flows into the feeding device as uniformly as possible and to enable a consistent screw fill. Again, the more stable or uniform the material flow is, the easier it is for the weighing and control system to provide optimal secondto- second performance. There are several types of material flow aids available such as:
Area Classifications / Explosivity Concerns
When specifying feeder requirements, it is very important to specify exactly the area classification for the feeder environment and explosivity ratings of the material to be processed. In the case of ATEX classifications, it is important to specify ratings of both the internal and external feeder environments, as these classifications and the resultant designs / electrical devices which must be chosen will certainly affect overall feeder cost.
Figure 6: The Coperion K-Tron Microfeeder feed module is easily exchanged without tools
In the case of an explosive material, it should also be discussed if an inert environment is required. Some manufacturers may include as standard purged shaft seals for their feed screws as well as internal agitators. If the feeder needs to be nitrogen inerted, these shaft seals can also be purged with nitrogen and gas connections can be added on the feeder hopper and feeder downspout. These additional connections may also add cost.
The containment of a pharmaceutical powder feeder can be important on two levels: protecting the operator from the product, and/or protecting the product from the environment. Dependent upon the potency of the API or drug compounds, a variety of feeder containment options are available. These options can includes the use of split butterfly valves on the feeder inlet and discharge connections, modifications for use within glove boxes or isolators, or even specialized designs which can be autoclaved or sterilized in place. All of these options should be discussed in detail with the feeder manufacturer to determine the optimal solution for the application, as well as effects on feeder cost and most importantly, process/product safety.
Overall Ergonomic Design and Accessibility
It should be noted that a variety of design options exist on the market for ease in accessibility. As a minimum, it is important to consider those which include quick release design features such as tri-clover clamps in lieu of bolted flanges and quick disconnects for electrical components, as well as quick removal screw configurations. In addition, feeder designs exist which allow for multiple exchange modules to achieve a variety of feed ranges within the same drive and scale configuration, as shown in Figure 6.
Wherever possible, re-configuring one feeder to perform the function of two or more is far preferable to the added procurement cost and ongoing time consumed in continually switching out and maintaining multiple feeders.
When discussing overall feeder configurations, there are a variety of important questions to be considered regarding upstream and downstream processes. For example, in the case of continuous LIW feeding, how will the feeder be refilled? Which options are available for the interface between the refill device and the feeder and is it certain that these options will not impact feeder performance? Which options are available for a multi feeder system that will help to make the feeders more accessible? The answers to these questions may affect the recommended feeder configuration as well as the overall cost. Design features such as rotating turntables, specialty roll out carts or tracks, and lift devices will all aid in improving the ergonomics of the feeder configuration as well as total time required for cleaning and changeover. Any small efficiency gained in the cleaning operation will be multiplied through time and by this generate a considerable reduction of the running costs. (for further information on feeder refill see white paper T-900017 “Smart Refill Technology in Loss-in-Weight Feeding”)
Method of Cleaning
In addition to the mechanical design features mentioned above, there are a number of features which can be added to the feeder dependent upon the method of cleaning. When considering wet cleaning, for example, it is important to discuss if a wash-in-place or rinse-in-place method of cleaning will help to improve your overall cleaning turnaround times. In these cases, options such as retractable spray ball assemblies and specially pitched frames to allow for drainage can be provided for the feeder, as well as a recommended cleaning protocol to ensure optimal initial wash cycles.
A knowledgable feeder manufacturer can advise design options which can reduce your cleaning and reassembly times.
The overall design and engineering of a pharmaceutical powder feeder can include a variety of options which can significantly increase the efficiency of operation. It is important to evaluate these options when evaluating true overall feeder cost from a capital investment perspective as well as overall effect on operating and material costs. Too often the savings and process improvements that an efficient feeding system can produce over time are not considered at the time of purchase, with only the “up front” capital cost of the equipment reviewed initially. For this reason, it is imperative to discuss with the feeder supplier all of the options available in order to truly understand the returns on investment of the feeding technology, as well as ensuring the optimization of its performance.